Ever since being prescribed Cymbalta to treat my serious depression our sex life, for my wife and I, has been destroyed. Cymbalta doesn't lessen sex drive or even make an erection difficult, it just makes an ejaculation for a man nearly impossible. However, as you well may imagine, the lack of an ejaculation can definitely effect sex drive. If anyone has had similar experiences I, (we) would greatly your input. My erection can last for a very considerable time, even though I'm over 60, I just want suggestion that will bring our love making to a good conclusion.